Registration Dossier

Administrative data

Description of key information

The No Observed Adverse Effect Level (NOAEL) and the Low Observed Adverse Effect Level of the registered item 1-phenyl-3-methyl-5-pyrazolone (A039) was defined respectively as 20 mg/kg/day and 100 mg/kg/day according to the results of the key studies and the REACh regulation.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
NOAEL
20 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Additional information

Justification for classification or non-classification

The No Observed Effect Level (NOEL) and the Low Observed Adverse Effect Level of the registered item 1-phenyl-3-methyl-5-pyrazolone (A039) was defined respectively as 20 mg/kg/day and 100 mg/kg/day according to the results of the key studies (clinical signs, pathological changes of spleen, bodyweight, anemia) and the REACh regulation.