Registration Dossier

Administrative data

Description of key information

Acute oral toxicity : The oral LD50 of the test substance PHENYL METHYL PYRALOZONE is higher than 2000mg/kg in rats. Thus, the test material is not classified as hazardous for acute oral toxicity according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) criteria. Nevertheless, this substance is classified in Category 5 of GHS. (OECD Guideline 401, GLP, Klimisch 1)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Based on the results of the two key studies (OECD Guideline 401, GLP, Klimisch 1), giving a LD50 >2000 mg/kg bodyweight in the rats, and inducing hypokinesia clinical sign during 2 days, the registered substance 1-phenyl-3-methyl-5-pyrazolone is not classified as hazardous for acute oral toxicity according to the Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) criteria. Nevertheless, the substance is classified in Category 5 of Globally Harmonized System (GHS) of Classification and Labelling.