Registration Dossier
Registration Dossier
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EC number: 201-891-0 | CAS number: 89-25-8
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity : The oral LD50 of the test substance PHENYL METHYL PYRALOZONE is higher than 2000mg/kg in rats. Thus, the test material is not classified as hazardous for acute oral toxicity according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) criteria. Nevertheless, this substance is classified in Category 5 of GHS. (OECD Guideline 401, GLP, Klimisch 1)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the results of the two key studies (OECD Guideline 401, GLP, Klimisch 1), giving a LD50 >2000 mg/kg bodyweight in the rats, and inducing hypokinesia clinical sign during 2 days, the registered substance 1-phenyl-3-methyl-5-pyrazolone is not classified as hazardous for acute oral toxicity according to the Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) criteria. Nevertheless, the substance is classified in Category 5 of Globally Harmonized System (GHS) of Classification and Labelling.
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