Iron tris(phosphinate)

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

of read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxiicity of aquatic algae and cynobacteria for the test chemical :
1.Testing of Toxic Effects of test material on the Single Cell Green Algae Scenedesmus subspicatus.
2.To evaluate toxicity of aquatic algae and cyano-bacteria by test material

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material: Ferric hypophosphite
- IUPAC name: iron(3+) ion triphosphinate
- Molecular formula: FeO6P3
- Molecular weight: 250.8084 g/mole
- Smiles : [Fe+3].[O-]P=O.[O-]P=O.[O-]P=O
- Inchl: 1S/Fe.3H3O2P/c;3*1-3-2/h;3*3H2,(H,1,2)/q+3;;;/p-3
- Substance type: Inorganic
- Physical state: Solid powder (white to grey)

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Scenedesmus subspicatus , Pseudokirchneriella subcapitata

Details on test organisms:

No data availble

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Nominal and measured concentrations:

1.0.01, 0.1, 1 and 10 mg /L)

Details on test conditions:

1.The test was performed in a limit test design with 6 control vessels and 6 test vessels with the highest concentration of 100 mg/L.

Reference substance (positive control):

not specified

Duration:

72 h

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: Read across 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

200 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

biomass

Remarks on result:

other: Read across 2

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical Ferric hypophosphite is not likely to be toxic to fish atleast in the dose range of >100-200 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of aquatic algae and cynobacteria of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:

1.The growth inhibition effects of test chemical was tested with the green algae Scenedesmus subspicatus. The cell growth was measured 24, 48 and 72 hours after initiation of the test.

 The test was performed in a limit test design with 6 control vessels and 6 test vessels with the highest concentration of 100 mg/L.

The effect concentration of test chemial on Scenedesmus subspicatus was observed to be >100 mg/l.

2.Test material was used as a test material to evaluate its toxicity to aquatic algae and cynobacteria on Pseudokirchneriella subcapitata  . The effect concentration of test chemical was observed to be 200mg/l.

Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range >100 -200 mg/L. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite cannot be classified for toxicity to aquatic algae and cynobacteria .Hence,based on the data available for the structurally and functionally similar read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of >100 -200 mg/L .

Description of key information

Toxicity to aquatic algae and cynobacteria:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of aquatic algae and cynobacteria of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:

1.The growth inhibition effects of test chemical was tested with the green algae Scenedesmus subspicatus. The cell growth was measured 24, 48 and 72 hours after initiation of the test.

 The test was performed in a limit test design with 6 control vessels and 6 test vessels with the highest concentration of 100 mg/L.

The effect concentration of test chemial on Scenedesmus subspicatus was observed to be >100 mg/l.

2.Test material was used as a test material to evaluate its toxicity to aquatic algae and cynobacteria on Pseudokirchneriella subcapitata  . The effect concentration of test chemical was observed to be 200mg/l.

Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range >100 -200 mg/L. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite cannot be classified for toxicity to aquatic algae and cynobacteria .Hence,based on the data available for the structurally and functionally similar read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of >100 -200 mg/L .

Key value for chemical safety assessment

EC50 for freshwater algae:

200 mg/L

Additional information

Toxicity to aquatic algae and cynobacteria:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of aquatic algae and cynobacteria of the test chemical Ferric hypophosphite (7783 -84 -3).The studies are as mentioned below:

1.The growth inhibition effects of test chemical was tested with the green algae Scenedesmus subspicatus. The cell growth was measured 24, 48 and 72 hours after initiation of the test.

 The test was performed in a limit test design with 6 control vessels and 6 test vessels with the highest concentration of 100 mg/L.

The effect concentration of test chemial on Scenedesmus subspicatus was observed to be >100 mg/l.

2.Test material was used as a test material to evaluate its toxicity to aquatic algae and cynobacteria on Pseudokirchneriella subcapitata  . The effect concentration of test chemical was observed to be 200mg/l.

Thus, based on the above summarised studies, Ferric hypophosphite and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range >100 -200 mg/L. Thus, comparing this value with the criteria of CLP regulation, Ferric hypophosphite cannot be classified for toxicity to aquatic algae and cynobacteria .Hence,based on the data available for the structurally and functionally similar read across, test chemical Ferric hypophosphite is not likely to be toxic atleast in the dose range of >100 -200 mg/L .