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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
method of Draize and associates: only 4 animals used, number of dose levels not mentioned

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding toxicity data: List VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum J.S.
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 1969, 30:5, 470-476
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A.
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 1962, 23:2, 95-107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethyl phosphate
EC Number:
208-144-8
EC Name:
Trimethyl phosphate
Cas Number:
512-56-1
Molecular formula:
C3H9O4P
IUPAC Name:
trimethyl phosphate
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Type of wrap if used: impervious plastic film
Duration of exposure:
24 hour contact period
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
3 388 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: CLP criteria not met
Conclusions:
The LD50 dermal of Trimethyl phosphate is 3388 mg/kg bw.