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Diss Factsheets
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EC number: 947-057-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study conducted similarly to OECD Guideline 402 with deviations: purity of test substance, details on test animals and environmental conditions not reported, 2/sex/dose instead of 5/sex/dose
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- purity of test substance, details on test animals and environmental conditions not reported, 2/sex/dose instead of 5/sex/dose
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxy-3-[(1-oxodocosyl)oxy]propyltrimethylammonium chloride
- EC Number:
- 274-033-6
- EC Name:
- 2-hydroxy-3-[(1-oxodocosyl)oxy]propyltrimethylammonium chloride
- Cas Number:
- 69537-38-8
- Molecular formula:
- C28H58NO3.Cl
- IUPAC Name:
- 3-(docosanoyloxy)-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Reference substance name:
- 2-methylpentane-2,4-diol
- EC Number:
- 203-489-0
- EC Name:
- 2-methylpentane-2,4-diol
- Cas Number:
- 107-41-5
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-methylpentane-2,4-diol
- Test material form:
- solid
- Remarks:
- paste
- Details on test material:
- - Description: White pasty product
- Date of receipt: 10 September 1980
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Test substance was applied to a large surface of the skin at 0 (control), 5, 10 or 100% at 9 mL/kg bw of the rabbits during 24 hours. Each of the doses was applied to two male and two female rabbits. In each dose group one male and one female received the test substance on the intact skin, while the other male and female was treated on the superficially damaged skin. - Duration of exposure:
- 24 hours
- Doses:
- 5, 10 and 100% at 9 mL/kg bw
- No. of animals per sex per dose:
- 2 animals/sex/dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: After exposure, the animals were observed for a period of 14 days. Body weights, and intake of food and water were recorded. At day 14, blood samples were collected for examination of haematological parameters.
- Necropsy of survivors performed: Yes, at the end of observation period, animals were sacrificed and examined for gross pathological changes. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- as the relative density of test substance is equal to 1.011 at 20°C, the LD50 is higher than 9099 mg/kg bw
- Mortality:
- One rabbit in the lowest dose group and one of the controls died from causes apparently unrelated to treatment. No deaths occurred in the intermediate and high dose group.
- Clinical signs:
- No clinical signs were observed.
After the 24-hour exposure period only one top-dose rabbit showed signs of skin irritation. - Gross pathology:
- At autopsy of the survivors no gross changes attributable to the test substance were observed.
- Other findings:
- Body weight gain, food and water consumption and haematology did not show any treatment-related changes.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, the dermal LD50 of test substance is higher than 9 mL/kg bw or 9099 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study, test substance was applied to a large surface of the skin at 0 (control), 5, 10 or 100% at 9 mL/kg bw of the NewZealand White rabbits (2/sex/dose) during 24 hours. In each dose group one male and one female received the test substance on the intact skin, while the other male and female was treated on the superficially damaged skin. Animals were observed for mortality, clinical signs, bodyweights, food and water consumption and haematology for 14 days and at the end of the study the surviving animals were sacrificed for macroscopic examination.
One rabbit in the lowest dose group and one of the controls died from causes apparently unrelated to treatment. No deaths occurred in the intermediate and high dose group. After the 24-hour exposure period only one top-dose rabbit showed signs of skin irritation. General condition, body weight gain, food and water consumption and haematology did not show any treatment-related changes. No abnormalities were noted at necropsy.
Under the test conditions, no treatment-related death was observed up to 9 mL of the undiluted product/kg bw. As the relative density of test substance is equal to 1.011 at 20°C, the dermal LD50 of test substance is higher than 9099 mg/kg bw.
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