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EC number: 206-616-8 | CAS number: 358-23-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation study: based on the results of the in vivo study
(Gomond, 2005), trifluoromethansulfonic anhydride is considered as
corrosive to the skin category 1B.
Eye irritation: based on the corrosivity of trifluoromethanesulfonic
anhydride, a waiving was proposed.
Respiratory irritation: no specific study is available, however it can
be presumed from the corrosive effects on skin that
trifluoromethanesulfonic anhydride may cause respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2005-02-07 to 2005-02-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Grimaud supplier (49450 Roussay, France)
- Age at study initiation: no data
- Weight at study initiation: 2.83 kg
- Fasting period before study: no
- Housing: individually housed in stainless steel cage on floor grid (60cm x 45 cm x 32cm)
- Diet (e.g. ad libitum): complete diet from Ergilap Anco
- Water (e.g. ad libitum): no data
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 °C
- Humidity (%): 50 +/- 20 %
- Air changes (per hr): 10 cycles/hour
- Photoperiod (hrs dark / hrs light): 12h/12h
IN-LIFE DATES: 2005-02-07 to 2005-02-22 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): not applicable, the test item is applied undiluted
VEHICLE
not applicable, the test item is applied undiluted - Duration of treatment / exposure:
- 3 min and 1 hour. Two sites in the same animal were treated with the test item.
The 4 hour treatment was not performed for ethical reasons - Observation period:
- 1 hour after the end of exposure then daily for 14 days.
- Number of animals:
- one animal.
two other animal were planned but not used for ethical reasons. - Details on study design:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- % coverage: 6.25 cm² (2.5 x 2.5 cm)
- Type of wrap if used: Micropore tape 5cm x 5 cm.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data.
- Time after start of exposure: 3 min and 1 hour.
SCORING SYSTEM: according to guideline - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- Mean individual score after 3 min exposure
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis on day 11
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- Mean individual score after 3 min exposure
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis on day 11
- Irritant / corrosive response data:
- After 3 min application : Moderate erythema within 1 hour (score 2). Erythema is becoming more severe in time and reaches a score of 4 at day 7. Eschar formation was observed at day 7 and scar at day 14.
After 1 hour application : Necrosis is observed after 1 hour observation. - Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Under the test conditions, the test item trifluoromethanesulfonic anhydride is classified as Skin Corr./Irr. 1B (H314; causes severe skin burns and eye damage) when applied topically to rabbits according to the criteria of the Regulation (EC) 1272/2008 (CLP).
- Executive summary:
In a GLP dermal irritation study (Gomond 2005) performed according to the OECD No. 404, one New Zeland White rabbit was dermally exposed to 0.5 mL of undiluted trifluoromethanesulfonic anhydride to the dorsal surface of the trunk (skin was shaved before application). Two test sites were covered with a semi-occlusive dressing and tested in the same animal corresponding to 2 different time of exposure: 3 min and 1hr. After the removal of the gauze patch, animals were then observed for 14 days. Skin irritation was assessed and scored at 1, 24, 48, 72 hrs and daily for 14 days after the end of the exposure. The 4 hours exposition time and the treatment of 2 additional rabbits was ot performed for ethical reason and because the results were clear enough to allow conclusion on classification.
The application for 3 minutes of 0.5 ml of the test item to the skin of one rabbit induced a well-defined erythema from D1 to D3, then a moderate to severe erythema from D4 to D13, associated with a moderate to slight edema. The reversibility of the reactions was not complete on D14. On D7 eschar formation was observed and on D14 when the scab was fallen as was noted.
The application of 0.5 ml of the test item for 1 hour induced since the first hour, the formation of a grey necrosis. A severe edema was observed on D2. After desquamation of scab on D13 a scar appeared. On D14, the reversibility was not complete. Presence of a scar, with 3 minutes patch, on D14, indicative of tissue lesions on the whole skin thickness
In conclusion, under the test conditions, the test item trifluoromethanesulfonic anhydride is classified as Skin Corr./Irr. 1B (H314; causes severe skin burns and eye damage) when applied topically to rabbits according to the criteria of the Regulation (EC) 1272/2008 (CLP).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
- In a GLP dermal irritation study (Gomond 2005) performed according to the OECD No. 404, one New Zeland White rabbit was dermally exposed to 0.5 mL of undiluted trifluoromethanesulfonic anhydride to the dorsal surface of the trunk. The application for 3 minutes of 0.5 ml of the test item to the skin of one rabbit induced a well-defined erythema from D1 to D3, then a moderate to severe erythema from D4 to D13, associated with a moderate to slight edema. The reversibility of the reactions was not complete on D14. On D7 eschar formation was observed and on D14 when the scab was fallen as was noted.
The application of 0.5 ml of the test item for 1 hour induced since the first hour, the formation of a grey necrosis. A severe edema was observed on D2. After desquamation of scab on D13 a scar appeared. On D14, the reversibility was not complete. Presence of a scar, with 3 minutes patch, on D14, indicative of tissue lesions on the whole skin thickness
Under the test conditions, the test item trifluoromethanesulfonic anhydride is classified as corrosive to skin into category 1B (H314; causes severe skin burns and eye damage) when applied topically to rabbits according to the criteria of the Regulation (EC) 1272/2008 (CLP).
Eye irritation:
Trifluoromethanesulfonic anhydride is considered as corrosive (Cat 1B, H314). Therefore, according to the column 2 of the Annex VIII of the Regulation (EC) NO. 1907/2006 (REACh) (section 8.2.1), an in vivo eye irritation study does not need to be conducted if the substance is classified as corrosive to the skin.
Respiratory irritation:
No specific study is available, however it can be presumed from the corrosive effects on skin and the volatility (vapour pressure: 70.93 hPa at 20°C and 93.18 hPa at 25° C) that trifluoromethanesulfonate anhydride should cause respiratory irritation.
Justification for classification or non-classification
Skin irritation:
Based on the above data, trifluoromethanesulfonic anhydride is classified as corrosive into category 1B (H314; causes severe skin burns and eye damage)according to the criteria of the Regulation (EC) 1272/2008 (CLP).
Eye irritation:
No data is available. However, as the substance is classified as corrosive, no further test has to be conducted. As mentioned in the Guidance on the application of Regulation (EC) No 1272/2008, a skin corrosive substance is considered to also cause serious eye damage which is included in the hazard statement for skin corrosion (H314: causes severe skin burns and eye damage).
Respiratory irritation:
No specific study is available, however it can be presumed from the corrosive effects on skin and the volatility (vapour pressure: 70.93 hPa at 20°C and 93.18 hPa at 25° C) that trifluoromethanesulfonic anhydride should cause respiratory irritation and is classified as STOT SE Cat.3, H335 according to the Regulation (EC) No 1272/2008 criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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