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EC number: 206-616-8 | CAS number: 358-23-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 22 May 2012 to 20 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 1.604 other: g/ml
- Temp.:
- 20 °C
- pH:
- 0
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of the test item at 20°C was >= 1.6040 g/ml. The test item is considered as soluble in water. - Executive summary:
The water solubility was determined by Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and GLP. No deviation from the Guidelines was observed during the test.
The solubility of a solid or liquid chemical can be defined as the maximum amount of the chemical (the solute) in solution at equilibrium with excess chemical present at specific conditions (temperature and atmospheric pressure). The water solubility of a substance is specified by the saturation mass concentration of the substance in water and is a function of temperature.
The visual observations made during the preliminary and definitive test demonstrate that the test item is freely miscible in water. The results of incremental additions of the test material to purified reagent water demonstrate that the test item completely dissolved in purified reagent water at a ratio of 1.6040 g of test item to 1.0 mL of purified reagent water. The test item is considered as soluble in water.
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- The read-across justification is provided in the attached document.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Water solubility:
- >= 1 604 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: By analogy with the hydrolysis product
- Conclusions:
- By analogy with its degradation product in water, the water solubility of trifluoromethanesulfonic anhydride is considered to be above 1604 g/L at 20°C.
- Endpoint:
- water solubility
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Referenceopen allclose all
Preliminary test results:
During the preliminary test, 0.1 mL of purified reagent water, when added carefully to 0.1024 g of test item, wholly dissolved into the acid. The resulting solution was clear and transparent. The mixture was observed to have no visible separation. The pH was tested using pH paper and was determined to be 0. Because there was no visible separation, the mixture was not observed after 24 hours.
Definitive test results:
The observations made in the definitive test are shown in the folloing table:
|
Observations |
||||||
Amount of Test item (g) |
Total Volume of Test item (mL) added to 1 ml of water (mL) |
||||||
0.1 |
0.5 |
0.75 |
1.0 |
||||
1.6040 |
Clear; no visible layers |
Clear; no visible layers |
Clear; no visible layers |
Clear; no visible layers |
|||
|
Amount of Test item Added (g) |
||||||
0.1660 |
0.6367 |
0.4016 |
0.3997 |
Since the test substance is miscible in water, observations were made after the sample was added. If the test substance was found to be soluble, more test material was added (the additional test substance was weighed and recorded in order to determine total weight of test substance added). The solution was then shaken for 10 minutes and found to have no undissolved test material.
The definitive test demonstrated the immediate and thorough dissolution of test item into water. Incremental additions of the test
material, for a total of 1.6040 g (1 mL) to 1.0 mL of purified reagent water, each dissolved, forming a clear homogenous solution. The visual observations made during the preliminary and definitive test demonstrate that the test substance is freely miscible in purified reagent water. The results of this study demonstrate that test item completely dissolves in purified reagent water at a ratio of 1.6040 g of test item to 1.0 mL of purified reagent water.
Description of key information
Trifluoromethanesulfonic anhydride is rapidly hydrolysed in water, therefore it is not technically possible to measure a water solubility for this substance. The water solubility of the degradation product, i.e. trifluoromethanesulfonic acid, is considered as relevant for the assessment of trifluoromethanesulfonic anhydride.
The experimental determination of water solubility of trifluoromethanesulfonic acid was performed according to OECD TG 105 and GLP. The water solubility of the test item was found to be >= 1.6040 g/mL at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 1 604 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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