Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-950-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Aquatic algae studies performed according to EPA OTS 797.1050 or OECD TG 201 on source substances are available for read across purposes. In each of these studies, the 96 hour Effective Loading Rate was equivalent to the highest concentrations tested.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
Aquatic algae studies on read across source substances were performed according to EPA OTS 797.1050 or OECD TG 201. In each of these studies, the 96 hour Effective Loading Rate was equivalent to the highest concentrations tested. A series of 96-hour acute toxicity algal studies were performed on several substances using cultures of Selenastrum capricornutum (now Pseudokirchneriella subcapitata) (Ward, 1994). The first algal exposure was to test substance CASN 115733-09-0 at nominal concentrations of 100, 300 and 1000 mg/L as WAF loadings under static conditions in accordance with the EPA OTS 797.1050. Daily cell counts were made visually by means of direct microscopic examination with a hemocytometer. At 72-hours cell density measurements in the treatments were 80%, 62% and 70% of the control at 100, 300 and 1000 mg/L, respectively. At 96-hours cell density measurements in the treatments were 70%, 66% and 88% of the control at 100, 300 and 1000 mg/L, respectively. At 72-hours, specific growth rate measurements were 95%, 90% and 92% of the control at 100, 300 and 1000 mg/L WAF, respectively. At 96-hours, specific growth rate measurements were 93%, 92% and 97% of the control at 100, 300 and 1000 mg/L WAF, respectively. The 72-hour and 96-hour Effective Loading Rate (EL50) was >1000 mg/L nominal WAF. The 72-hour and 96-hour No Observed Effect Levels (NOEL) was 1000 mg/L nominal WAF based on both specific growth rate and cell density.
The next substance tested in the same study was CAS 71486-79-8 (Ward, 1994). Nominal concentrations of 100, 300 and 1000 mg/L as WAF loadings under static conditions were performed on green algae in accordance with the EPA OTS 797.1050. At 72-hours cell density measurements in the treatments were 133%, 75% and 64% of the control at 100, 300 and 1000 mg/L, respectively. At 96-hours cell density measurements in the treatments were 93%, 77% and 52% of the control at 100, 300 and 1000 mg/L, respectively. At 72-hours, specific growth rate measurements were 108%, 92% and 88% of the control at 100, 300 and 1000 mg/L WAF, respectively. At 96-hours, specific growth rate measurements were 98%, 95% and 86% of the control at 100, 300 and 1000 mg/L WAF, respectively. The 72-hour and 96-hour Effective Loading Rate (EL50) was >1000 mg/L and the 72-hour and 96-hour No Observed Effect Concentrations (NOEL) was 1000 mg/L based on both specific growth rate and cell density.
The final substance used in the study by Ward (1994) was CASN 71486-47-5. Green algae were dosed at nominal concentrations of 125, 250, 500, 1000 and 1500 mg/L as WAF loadings under static conditions in accordance with the EPA OTS 797.1050. At 72-hours cell density measurements in the treatments were 97%, 100%, 101%, 95% and 25% of the control at 125, 250, 500, 1000 and 1500 mg/L respectively. At 96-hours cell density measurements in the treatments were 78%, 61%, 62%, 58% and 31% of the control at 125, 250, 500, 1000 and 1500 mg/L respectively. At 72-hours, specific growth rate measurements were 100%, 100%, 100%, 98% and 75% of the control at 125, 250, 500, 1000 and 1500 mg/L WAF, respectively. At 96-hours, specific growth rate measurements were 95%, 91%, 91%, 89% and 72% of the control at 125, 250, 500, 1000 and 1500 mg/L WAF, respectively. The 72-hour Effective Loading Rate (EL50) was 1400 mg/L and >1500 mg/L based on cell density and specific growth rate, respectively. The 96-hour Effective Loading Rate (EL50) = 1100 mg/L and >1500 mg/L based on cell density and specific growth rate, respectively. The 72-hour and 96-hour No Observed Effect Loading Rates (NOEL) were 1000 mg/l based on both specific growth rate and cell density.
In a 72 hour toxicity study, the cultures of the green algae (Scenedesmus subspicatus) were exposed to sulphonic acids, petroleum, calcium salts at nominal concentrations of 0 and 100 mg/L nominal WAF loading rate under static in accordance with the guideline OECD Guideline 201 (Alga, Growth Inhibition Test) (Mead, 2005). The 72 hour EC50 based on biomass was >100 mg/L WAF loading rate and the EC50 based on specific growth rate was >100 mg/L WAF loading rate. There was no compound related phytotoxic effects. The 72-hour NOEL (biomass and specific growth rate) was 100 mg/L WAF loading rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.