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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs :p-METHOXYPHENYLACETONE
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology,Volume 17, Supplement, Pages 695-923 (December 1979)
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity study of 4-Methoxyphenylacetone (122-84-9) in rabbits
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
secondary source
Title:
Acute oral toxicity study of 4-Methoxyphenylacetone (122-84-9) in rat
Author:
RTECS
Year:
2017
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity test was carried out to study the effects of 4-Methoxyphenylacetone (122-84-9) on rabbits.
GLP compliance:
no
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxyphenylacetone
EC Number:
204-578-7
EC Name:
4-methoxyphenylacetone
Cas Number:
122-84-9
Molecular formula:
C10H12O2
IUPAC Name:
1-(4-methoxyphenyl)propan-2-one
Details on test material:
- Name of test material (IUPAC name): 1-(4-methoxyphenyl)propan-2-one
- Common name: 4-Methoxyphenylacetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(C)=O
- InChl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):p-Methoxyphenylacetone
- Molecular formula :C10H12O2
- Molecular weight :164.203 g/mol
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rabbits at 5000 mg/kg bw
Mortality:
No mortality was observed in treated rabbits at 5000 mg/kg bw.
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 4-Methoxyphenylacetone (122-84-9) by dermal application.
Executive summary:

In acute dermal toxicity study,rabbits were treated with 4-Methoxyphenylacetone (122-84-9) in the concentration of 5000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 5000 mg/kg bw.Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 4-Methoxyphenylacetone (122-84-9) by dermal application.

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