Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-376-9 | CAS number: 120-20-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study of 2-(3,4-dimethoxyphenyl)ethan-1-amine (120-20-7) in rat
- Author:
- Jay A. Brown
- Year:
- 2 017
- Bibliographic source:
- Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine, October 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of 2-(3,4-dimethoxyphenyl)ethan-1-amine (120-20-7) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3,4-dimethoxyphenethylamine
- EC Number:
- 204-376-9
- EC Name:
- 3,4-dimethoxyphenethylamine
- Cas Number:
- 120-20-7
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 2-(3,4-dimethoxyphenyl)ethanamine
- Details on test material:
- Name: 2-(3,4-dimethoxyphenyl)ethan-1-amine
InChI:1S/C10H15NO2/c1-12-9-4-3-8(5-6-11)7-10(9)13-2/h3-4,7H,5-6,11H2,1-2H3
Smiles:COc1ccc(CCN)cc1OC
- Name of test material :Homoveratrylamine
- Molecular formula :C10H15NO2
- Molecular weight :181.2335 g/mol
- Substance type:organic
Constituent 1
- Specific details on test material used for the study:
- Name: 2-(3,4-dimethoxyphenyl)ethan-1-amine
InChI:1S/C10H15NO2/c1-12-9-4-3-8(5-6-11)7-10(9)13-2/h3-4,7H,5-6,11H2,1-2H3
Smiles:COc1ccc(CCN)cc1OC
- Name of test material :Homoveratrylamine
- Molecular formula :C10H15NO2
- Molecular weight :181.2335 g/mol
- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- not specified
- Concentrations:
- 5500 mg/m3 (5.5 mg/L)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 5 500 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 5500 mg/m3
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) was considered to be >5500 mg/m3, when rats were exposed with 2-(3,4-dimethoxyphenyl)ethan-1-amine (120-20-7) by inhalation route for 4 hours.
- Executive summary:
The acute inhalation toxicity study was conducted by using2-(3,4-dimethoxyphenyl)ethan-1-amine (120-20-7) in rats at concentration of 5500 mg/m3. No mortality was observed at 5500 mg/m3. Therefore, LC50 was considered to be >5500 mg/m3, when rats were exposed with2-(3,4-dimethoxyphenyl)ethan-1-amineby inhalation route for 4 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
