Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from handbook, authoritative and modeling database
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of octanol water partition coefficient of the test substance 2-(3,4-dimethoxyphenyl)ethan-1-amine.
GLP compliance:
not specified
Type of method:
other: No data available
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Name of the test material (IUPAC name): 2-(3,4-dimethoxyphenyl)ethan-1-amine
- Common name: 3,4-dimethoxyphenethylamine
- Molecular weight: 181.2335 g/mole
- Molecular formula: C10H15NO2
- Smiles: COc1ccc(CCN)cc1OC
- Inchl: 1S/C10H15NO2/c1-12-9-4-3-8(5-6-11)7-10(9)13-2/h3-4,7H,5-6,11H2,1-2H3
- Substance type: Organic
- Physical state: Liquid
Key result
Type:
log Pow
Partition coefficient:
0.77
Remarks on result:
other: Other details not known
Details on results:
The logKow of test chemical 2-(3,4-dimethoxyphenyl)ethan-1-amine was determined to be 0.77.
Conclusions:
The partition coefficient (log Pow) value of the substance 2-(3,4-dimethoxyphenyl)ethan-1-amine was determined to be 0.77.
Executive summary:

The partition coefficient (log Pow) value of the substance 2-(3,4-dimethoxyphenyl)ethan-1-amine was determined to be 0.77. Based on this value, chemical 2-(3,4-dimethoxyphenyl) ethan-1-amine can be considered to be hydrophilic in nature.

Description of key information

Based on the available data from handbook, authoritative and modelling databases, the partition coefficient (log Pow) value of the substance 2 -(3,4 -dimethoxyphenyl) ethan-1 -amine was determined to be 0.77. On the basis of this experimental value, chemical 2 -(3,4 -dimethoxyphenyl) ethan-1 -amine can be considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.77

Additional information

Based on the available data from handbook, authoritative and modelling databases, the partition coefficient (log Pow) value of the substance 2 -(3,4 -dimethoxyphenyl) ethan-1 -amine was determined to be 0.77. On the basis of this experimental value, chemical 2 -(3,4 -dimethoxyphenyl) ethan-1 -amine can be considered to be hydrophilic in nature.