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EC number: 277-155-8 | CAS number: 72968-81-1
Individual and Mean Scores for Cornear lris and Conjunctivae for EU Labelling Regulations
Individual Scores for Ocular Irritation
S = orange caloured staining
Sf = orange staining of the fur around the eye
A study was performed to assess the irritation of the test material to the eye of the New Zealand White rabbit. The method followed OECD Guidelines No. 405 and Method B5 of Commission Directive 92/69/EEC. A single application 0.1 ml (93 mg)of the test material was administered to the non irrigated eye of three rabbits. Ocular effects were recorded 1, 24, 48 and 72 hours and 7 days after administration.
Individual reactions included orange coloured staining of the eye and fur surrounding the eye, translucent corneal opacity, iridial inflammation and minimal to moderate conjunctival irritation.
Maximum Group Mean Score: 14.3, mild irritant (class 4 on 1-8 scale)
The mean values from gradings at 24, 48 and 72 hours were lower than 1 for corneal opacity, lower than 1 for iritis, lower than 2 for both conjunctival redness and oedema, in at least two of three tested animals.
Therefore, the substance does not meet the criteria to be classified as eye irritating, according to the CLP Regulation (EC) No 1272/2008.
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