Registration Dossier
Registration Dossier
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EC number: 205-851-3 | CAS number: 156-38-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs: Phenylacetic acid
- Author:
- D.L.J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 13, Issue 6, 1975, Pages 901-902
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of Phenylacetic acid (103-82-2) was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Phenylacetic acid
- EC Number:
- 203-148-6
- EC Name:
- Phenylacetic acid
- Cas Number:
- 103-82-2
- Molecular formula:
- C8H8O2
- IUPAC Name:
- phenylacetic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Phenylacetic acid
- Molecular formula :C8H8O2
- Molecular weight :136.149 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Phenylacetic acid
- Molecular formula :C8H8O2
- Molecular weight :136.149 g/mol
- Substance type:Organic
- Physical state:Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose 5000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The acute dermal median lethal dose (LD50) of phenylacetic acid in Rodent - rabbit was considered to be >5000 mg/kg of body weight via dermal application.
- Executive summary:
Acute dermal toxicity study was done in rat using test materialPhenylacetic acid(103-82-2). No mortality was observed at dose 5000mg/kg bw. HenceLD50 was considered to be >5000mg/kg body weight,when rats were treated withPhenylacetic acid(103-82-2)by dermal application.
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