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Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 4-Hydroxybenzoic Acid (99-96-7) in rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
publication
Title:
Acute oral toxicity study in rat for CAS no: 99-96-
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
Gestis Substance Database ,2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of 4-Hydroxybenzoic Acid (99-96-7) on rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hydroxybenzoic acid
EC Number:
202-804-9
EC Name:
4-hydroxybenzoic acid
Cas Number:
99-96-7
Molecular formula:
C7H6O3
IUPAC Name:
4-Hydroxybenzoic acid
Details on test material:
- Name of test material (IUPAC name): 4-Hydroxybenzoic Acid
- Common name: 4-Carboxyphenol
- Molecular formula: C7H6O3
- Molecular weight: 138.1214 g/mol
- Smiles notation: c1(C(=O)O)ccc(cc1)O
- InChl: 1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):4-Hydroxybenzoic Acid
- Molecular formula :C7H6O3
- Molecular weight :138.1214 g/mol
- Substance type:organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Details on study design:
- Other examinations performed: clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at dose 10000 mg/kg bw
Clinical signs:
other: Clinical signs like dyspnea and muscle weakness were observed
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be >10000 mg/kg bw,when rats were treated with 4-Hydroxybenzoic Acid (99-96-7) orally.
Executive summary:

Acute oral toxicity study was performed in rats using test material4-Hydroxybenzoic Acid(99-96-7).No mortality was observed at dose 10000 mg/kg bw.Clinical signs like dyspnea and muscle weakness were observed.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with 4-Hydroxybenzoic Acid(99-96-7)orally.