Reaction products of diazotised 2-amino-5-nitrobenzenesulfonic acid coupled with resorcinol, subsequently coupled with diazotized 2-amino-4-nitro-6-sulfo-phenol, chelated with iron, sodium salt

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Version / remarks:

1995

GLP compliance:

no

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

photometric method

Type:

Pow

Partition coefficient:

ca. 0.006

Temp.:

20 °C

pH:

ca. 6.22

Type:

log Pow

Partition coefficient:

ca. -2.252

Temp.:

20 °C

pH:

ca. 6.22

At 96 hours, value reached equilibrium, and so this value was considered for final calculations making duplicate determinations of every ratio o/w.

Concentration of mother solution: W₁ = 0.0404 g/100 mL = 0.4040 g/L

 

Ratio o/w	Water phase	n-octanol phase	Pow	log Pow	Avarage log Pow
	c (g/l)	c (g/l)
70 / 30	0.4031	0.0020	0.0050	-2.305044	-2.3050
70 / 30	0.4031	0.0020	0.0050	-2.305044
50 / 50	0.4014	0.0026	0.0064	-2.194052	-2.1941
50 / 50	0.4014	0.0026	0.0064	-2.194052
30 / 70	0.3989	0.0022	0.0055	-2.258211	-2.2582
30 / 70	0.3989	0.0022	0.0055	-2 .258211

 

Average P_ow: 0.0056 ± 0.0007

Average logP_ow: -2.2524 ± 0.056

Conclusions:

logPow = -2.2524;
Pow = 0.0056

Executive summary:

Method:

Partition coefficient was determined by means of shake flask method as per recommendations of OECD 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

Results:

The partition coefficient of the tested substance at 20°C and pH = 6.22 is logPow = -2.2524 and Pow = 0.0056.

Description of key information

OECD TG 107 - logPow = -2.2524 at 20°C and pH 6.22

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.252

at the temperature of:

20 °C