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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 - 07 November 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
27th July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
Regulation (EC) No 440/2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Swiss GLP compliance programme (inspected on November 15 and 16, 2011/ signed on May 01, 2012)
Type of method:
method to determine freezing temperature
Remarks:
Method for the Determination of Crystallizing Point (BS4633)
Specific details on test material used for the study:
STORAGE CONDITIONS OF TEST MATERIAL
Refrigerator (between 0 and 10 °C under nitrogen)
Key result
Melting / freezing pt.:
< 253 K

Table 4.2/1: Determinations 1 and 2

Determination 1 Time (s)

Temperature (K)

Determination 2 Time (s)

Temperature (K)

0

299

0

297

30

295

30

294

60

291

60

291

90

287

90        

289

120

285

120

285

150

282

150

282

180

278

180

279

210

276

210

277

240

275

240

275

270

272

270

273

300

270

300

271

330

268

330

268

360

265

360

265

390

263

390

262

420

261

420

260

450

258

450

258

480

256

480

257

510

254

510

254

540

253

540

253

570

251

570

252

600

250

600

251

-

-

630

251

-

-

660

250

 

Observations: Test substance changed in appearance during cooling.

The freezing temperature of test substance has been determined to be < -20 ± 0.5 °C (< 253 ± 0.5 K).

Conclusions:
No further testing required (< -20°C).
Executive summary:

The freezing point of the test substance was determined according to OECD 102/EU A1 guideline using BS4633 method for the determination of crystallizing point.

The determination was carried out in duplicate and the mean final temperature was retained.

No steady state was observed during cooling, so the freezing temperature of test substance has been determined to be < -20 ± 0.5°C (< 253 ± 0.5 K).

Description of key information

Freezing point < -20°C.

No further testing required.

Key value for chemical safety assessment

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. As no freezing was observed down to -20°C, the result is expressed as a limit value, and cannot be retained as key data.