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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
mouse
Strain:
CBA:J
Sex:
female

Study design: in vivo (LLNA)

Vehicle:
propylene glycol
Concentration:
12.5%, 25% and 50%
No. of animals per dose:
4
Positive control substance(s):
hexyl cinnamic aldehyde (CAS No 101-86-0)

Results and discussion

Positive control results:
SI 3.6

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Value:
0.5
Test group / Remarks:
For the mice treated at 12.5%
Parameter:
SI
Value:
0.5
Test group / Remarks:
For the mice treated at 25%
Parameter:
SI
Value:
0.8
Test group / Remarks:
For the mice treated at 50%

Applicant's summary and conclusion