Registration Dossier
Registration Dossier
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EC number: 276-127-2 | CAS number: 71873-51-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 30th, 2017 to January 12th, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted: 27 July 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 55.13 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 - 72
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The solubility of the test item in milli-Q water was determined to be 55.12 g/l, 55.11 g/l and 55.17 g/l for replicates Flask 1 (24 Hours), Flask 2 (48 Hours) and Flask 3 (72 Hours) respectively. The mean water solubility resulted to be 55.13 g/l at 20 °C, with 0.06 % RSD and within the limit of 15 % for three time points.
- Conclusions:
- 55.13 g/l at 20 °C and pH 7.0
- Executive summary:
The water solubility of test item was determined in acordance with the OECD guideline 105 and United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances (TS-7101), Product Properties Test Guidelines, OPPTS 830.7840, EPA 712-C-98-041 March 1998. The analytical method was validated in accordance with SANCO/3029/99, rev 4.0 dated 11/07/00. The parameters such as specificity, linearity, accuracy and precision were verified during validation of the HPLC-UV method validation.
During the preliminary test, the test item solubility resulted to be more than 10-2 g/l, thus the shake flask method was chosen for the definitive test , which was performed in milli-Q water and under laboratory temperature condition of 20 °C. The samples were analyzed for test item concentration by high performance liquid chromatography and the solubility of test item was determined to be 55.13 g/l at 20 °C and pH 7.0.
Conclusion
55.13 g/l at 20 °C and pH 7.0
Reference
| Day | Test item content (g/l) | pH |
| 24 hours | 55.12 | 7.0 |
| 48 hours | 55.11 | 7.0 |
| 72 hours | 55.17 | 7.0 |
| Average | 55.13 | |
| SD | 0.032 | |
| % RSD | 0.06 |
Description of key information
55.13 g/l at 20 °C and pH 7.0
Key value for chemical safety assessment
- Water solubility:
- 55.13 g/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - Shake flask method
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