Registration Dossier
Registration Dossier
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EC number: 206-167-8 | CAS number: 305-72-6
Endpoint summary
Administrative data
Description of key information
Short-term EC50 values for alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) are available for two trophic levels of the aquatic freshwater compartment (aquatic invertebrates, aquatic plants).
The acute toxicity of alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) to duckweed Lemna minor was determined in a 7 day semi-static test according to OECD guideline 221. The median effect concentrations (EC50) of alpha-Ketoglutarate disodium salt on duckweed Lemna minor were estimated to be >7 mg/l measured concentration after 7 d of exposure. The NOEC values were determined to be 7 mg/l measured concentration after 7 d of exposure. The results of the test can be considered reliable without restriction.
The acute toxicity of alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) to Daphnia magna was determined in a 48 hour semi-static test according to OECD guideline 202. The median effect concentrations (EC50) of alpha-Ketoglutarate disodium salt on Daphnia magna were estimated to be >100 mg/l nominal concentration after 24 and 48 h of exposure. The NOEC values were determined to be 100 mg/l nominal concentration after 24 and 48 h of exposure. The results of the test can be considered reliable without restriction.
Conclusion on classification
The environmental classification of alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >7 mg/L (ErC50 for aquatic plants). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <= 1 mg/L).
Additional information
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