Registration Dossier
Registration Dossier
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EC number: 204-535-2 | CAS number: 122-34-9
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 July 1993 - 28 September 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105
- Version / remarks:
- with modifications to allow solubility in organic solvents to be determined
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6 (Water Solubility)
- Version / remarks:
- with modifications to allow solubility in organic solvents to be determined
- GLP compliance:
- yes
Test material
- Reference substance name:
- Simazine
- EC Number:
- 204-535-2
- EC Name:
- Simazine
- Cas Number:
- 122-34-9
- Molecular formula:
- C7H12ClN5
- IUPAC Name:
- 6-chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Test material: Simazine (pure)
- Appearance: White powder
- Batch No.of test material: Ref 766
- Expiration date of the batch: Two years from date of manufacture
- Purity: 99.5%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: In the dark at 4°C
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- acetone
- Solubility:
- 1.32 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Medium:
- other: dichloromethane
- Solubility:
- 0.576 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Medium:
- ethyl acetate
- Solubility:
- 0.852 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Medium:
- other: hexane
- Solubility:
- 0.001 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Medium:
- methanol
- Solubility:
- 0.694 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Medium:
- toluene
- Solubility:
- 0.111 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Mean result
- Test substance stable:
- yes
- Details on results:
- Calibration data gave correlation coefficients of 0.99984, 0.99989, 0.99925 and 0.99925 respectively, showing the detector response to be linear in the concentration ranges employed. Quality control data yielded a mean % of the nominal concentration of 99.6%.
Solvent blanks exhibited no peaks at the characteristic retention volume of simazine, showing the analytical methods to be free from interferences.
Applicant's summary and conclusion
- Conclusions:
- The solubility of simazine (pure) in acetone is 1.32 g/L at 20°C.
The solubility of simazine (pure) in dichloromethane is 0.576 g/L at 20°C.
The solubility of simazine (pure) in ethyl acetate is 0.852 g/L at 20°C.
The solubility of simazine (pure) in hexane is 7.36E-04 g/L at 20°C.
The solubility of simazine (pure) in methanol is 0.694 g/L at 20°C.
The solubility of simazine (pure) in toluene is 0.111 g/L at 20°C.
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