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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity, LD50: > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Acute Oral Toxicity

The acute oral toxicity was determined according to the EU Method B.1 (Acute Toxicity (Oral), in GLP.

In the Preliminary Study the test item was administered to one female at the dose of 500 mg/kg.

As no mortality was recorded in the animal, another female was administered atthe dose of 2000 mg/kg, and this too survived the treatment.

In the Main Study, ve males and ve females were treated at the dose of 2000 mg/kg and nomortality was recorded, hunched back, ataxia, irritability and liquid dark feaces were observed.

Justification for classification or non-classification

Acute oral toxicity

According to the CLP Regulation 1272/2008/EC, section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria shown in Table 3.1.1:

Oral (mg/kg body weight)

Category 1: LD50 ≤ 5

Category 2: 5 <LD50 ≤ 50

Category 3: 50 < LD50 ≤ 300

Category 4: 300 < LD50 ≤ 2 000

The oral LD50 values are > 2000 mg/kg/body weight.

The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n.1272/2008.