Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

2,3,3-Trimethyl-3H-indole-5-carboxylic acid shall be registered under REACH as transported isolated intermediate (Article 18 < 1000 t/a).

This indicative assessment of skin sensitizing properties is based on physico-chemical, toxicological, and in silico data. Experimental studies have not been performed for this endpoint.

The substance is of low acute oral toxicity in vivo and is not irritating to rabbit’s skin. In occupational settings no skin effects as skin irritation or skin sensitization were reported. The substance showed no electrophilicity in an Ames test in vitro.

According to the physico-chemical properties of the substance (solid, moderate solubility in water, log Pow 3.84) dermal absorption is not favoured but possible. However, the substance exerts no skin irritation potential that would facilitate penetration through the stratum corneum. No skin sensitization alerts were identified in silico by the OECD Toolbox.

In conclusion, the limited available information in this indicative evaluation does not point to a relevant skin sensitization potential in vivo.

Key value for chemical safety assessment

Justification for classification or non-classification

The substance is registered under Article 18 (transported isolated intermediate) < 1000 t/a; no testing is required; however, an indicative assessment of potential skin sensitizing properties based on non-testing methods is included in this IUCLID.

In conclusion, the limited available information in this indicative evaluation does not point to a relevant skin sensitization potential in vivo.