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EC number: 274-426-2 | CAS number: 70210-30-9
Endpoint summary
Administrative data
Description of key information
Stability:
Hydrolysis:
According to Annex VIII column 2 the study does not need to be conducted because the substance is Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) is highly insoluble in water.
Biodegradation:
Biodegradation in water:
Biodegradability of test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) was estimated by using OECD QSAR tool box v3.4 by considering six closest read across chemical log Kow as primary descriptor. Percent biodegradation of the test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] was estimated to be 1.66 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] is not readily biodegradable.
Bioaccumulation:
Bioaccumulation: aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS No. 70210-30-9) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] is non bioaccumulative in food chain.
Transport and distribution:
Adsorption/desorption:
The Soil Adsorption Coefficient i.e. Koc value of test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] (CAS No. 70210-30-9) was estimated using EPI suite KOCWIN Program (v2.00) as 1960000000 L/kg (log Koc= 9.2922) by means of MCI method at 25 deg. C. This log Koc value indicates that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] has very strong sorption to soil and therefore test chemical has negligible migration potential to ground water.
Additional information
Stability:
Hydrolysis:
According to Annex VIII column 2 the study does not need to be conducted because the substance is Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) is highly insoluble in water.
Biodegradation:
Biodegradation in water:
Predicted data studies for target chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) and experimental studies for its structurally similar read across chemicals have been conducted and their results are summarized below.
In first predicted data study the biodegradability of test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) was estimated by using OECD QSAR tool box v3.4 by considering six closest read across chemical log Kow as primary descriptor. Percent biodegradation of the test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] was estimated to be 1.66 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] is not readily biodegradable.
Another predicted data study was done by using Estimation Programs Interface Suite (EPI suite, 2018) in this study the biodegradation potential of the test compound Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] (CAS no. 70210 -30 -9) was estimated in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] is expected to be not readily biodegradable.
Next study was experimental study done for read across chemical done from (UERL, 2016) in this study 28-days Manometric respirometry test was conducted following the OECD guideline 301 F to determine the ready biodegradability of the read across chemical tetrasodium 1-acetamido-2-hydroxy-3-(4-((4-sulphonatophenylazo)-7-sulphonato-1-naphthylazo))naphthalene-4,6- disulphonate(CAS No. 2519-30-4). The test system included control, test read across and reference item. The concentration of read across and reference item (Sodium Benzoate) chosen for the study was 20 mg/l and 30 mg/l, while that of inoculum was10ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for read across item and reference item. The BOD28 value of tetrasodium 1-acetamido-2-hydroxy-3-(4-((4-sulphonatophenylazo)-7-sulphonato-1-naphthylazo))naphthalene-4,6- disulphonate(CAS No. 2519-30-4) was observed to be 0.050mgO2/mg. ThOD was calculated as1.088 mgO2/mg. Accordingly, the % degradation of the read across item after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 4.596 %. Based on the results, the read across item, under the test conditions, was considered to be not readily biodegradable at 20 ± 1°C over a period of 28 days.
Next experimental study was done from authoritative data base (J check, 2017) for read across chemical in this study the read across chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (CAS no. 5160-02-1)was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD parameter. The initial concentration of read across chemical was 100 mg/L. After 2 weeks (14 days) test chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] showed 0 % biodegradability by BOD parameter and by taking activated sludge as inoculumin 14 days so it is concluded that read across chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] is not readily biodegradable.
Similarly one more study was done from authoritative database (J check, 2017) in this study the read across chemical tetrasodium 3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate (CAS no. 3214-47-9) was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD, TOC and HPLC parameters. The initial concentration of read across chemical was 100 mg/L and study design was of standard type. The read across chemical tetrasodium 3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate showed 13 % biodegradation by TOC parameter and 0 % biodegradation by other two parameters namely BOD and HPLC in 28 days. Based on percent biodegradability it is concluded that read across chemical tetrasodium 3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate is not readily biodegradable.
Last experimental study was done from another authoritative database (HSDB, 2017) in this study the read across chemical disodium 6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate (CAS no. 2783-94-0) showed 0.0% biodegradation by considering BOD as parameter in 5 days, and by taking sewage as inoculums. So it is concluded that read across chemical disodium 6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate is not readily biodegradable.
On the basis of all the studies mentioned above it can be concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9)is not readily biodegradable.
Bioaccumulation:
Bioaccumulation: aquatic/sediments:
Predicted data study for target chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) and three different experimental studies for its structurally similar read across chemicals have been conducted and their results are summarized below.\
The first study was predicted data study done by using BCFBAF Program (v3.00) model of Estimation Program Interface (EPI suite 2018) in this study the bio concentration factor (BCF) for Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS No. 70210-30-9) of test chemical was estimated to be 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] is non bioaccumulative in food chain.
Next study was done from authoritative database (HSDB, 2017) in this study the ionic character of read across chemical disodium 6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate(CAS no. 2783-94-0)suggests the potential for bioconcentration in aquatic organisms is expected to be low.
Similarly another experimental study was done from authoritative database (J check, 2017) in this study bioaccumulation experiment was conducted for 6 weeks for determination the bioconcentration factor (BCF) of read across chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate](CAS no: 5160-02-1) on test organism Cyprinus carpio. The vehicle used in the study was HCO-40, Crystal sugar, Concentration of vehicle used was 1st Concentration area: HCO-40 14 ppm(w/v), Crystal sugar 14 ppm(w/v),2nd Concentration area: HCO-40 1.4 ppm(w/v) Crystal sugar 1.4 ppm(w/v). Recovery ratio for test water was 1st concentration area : 96.1 %, 2nd concentration area : 95.4 %, Fish : 79.8 %, - Limit of detection : Fish : 0.25 ppm. The Nominal concentrations used in the study was 1st Concentration area: 0.7 mg/L(w/v), 2nd Concentration area: 0.07 mg/L (w/v)and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h>= 420 ppm(w/v).Thus according to static Fish test the bioconcentration factor (BCF) for read across chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate]was determined according static fish test. The BCF value was observed to be 0.9 – 1.8 L/kg at dose concentration 0.7 mg/L and 8.5 - 15 L/kg at dose concentration 0.07 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that read across chemical Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] is non bioaccumulative.
One more experimental study was done from same source as mentioned in above study ( J check, 2017) in this study the bioaccumulation test was conducted for 28 days for determination the bioconcentration factor (BCF) of read across chemical tetrasodium3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate (CAS no 3214-47-9) on test organism Cyprinus carpio.Recovery ratio was in Fish : 83.4 %, and Limit of quantitation was in Test water at 1st concentration area was 0.020 mg/L, and on 2nd concentration area was 0.0020 mg/L, Fish : 0.24 microg/g. Nominal concentrations used in the study are 1st Concentration area: 1.0 mg/L, 2nd Concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) LC50(96 h) > 600 mg/L. The lipid content at start of exposure was 2.18 % and at end of exposure was 4.19 %. Thus according to static Fish test the BCF value of read across chemical tetrasodium 3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate was observed to be ≤ 0.25-1.0 L/kg at dose concentration 1.0 mg/L and ≤ 0.25 L/kg at dose concentration 0.1 mg/L on the basis of lipid content on test organism Cyprinus carpio during 28 days period. These BCF values indicate that the substance tetrasodium 3,3'-[carbonylbis[imino(2-methyl-4,1-phenylene)azo]]bisnaphthalene-1,5-disulphonate is not bioaccumulative in fish and food chain as these values are far less than 2000 criteria.
On the basis of all the studies mentioned above it can be concluded that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo]benzenesulphonate] (CAS no. 70210-30-9) is non bioaccumulative in nature.
Transport and distribution:
Adsorption/desorption:
The Soil Adsorption Coefficient i.e. Koc value of test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] (CAS No. 70210-30-9) was estimated using EPI suite KOCWIN Program (v2.00) as 1960000000 L/kg (log Koc= 9.2922) by means of MCI method at 25 deg. C. This log Koc value indicates that test chemical Tetrasodium 2,2'-[1,4-phenylenebis[carbonylimino[2-acetamido-4,1-phenylene]azo]]bis[5-[(4-sulphonatophenyl)azo] benzenesulphonate] has very strong sorption to soil and therefore test chemical has negligible migration potential to ground water.
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