Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
For the QMRF and QPRF documents of the current study, please see attached reports under "attached full study report".

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The Neutral Hydrolysis Rate constant model based on two sub-models. The first one simulates the hydrolysis pathways of organic chemicals and the second component uses for predicting the rate of hydrolysis. First order kinetics is used to determine the kinetic constant and ultimate half-life on the basis of predicted neutral hydrolysis rate constant.
Linear least square method was used to estimate the model parameters.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Transformation products:
not measured
Dissipation DT50 of parent compound
Hydrolysis rate constant:
0.057 d-1
Details on results:
Please note: the detailed report as well as the related QMRF of the predicition is attached to this dossier entry.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes