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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-07-20 to 2017-07-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
TOXI-COOP Toxicological Research Center Zrt., H-8230 Balatonfüred, Arácsi út 97-99. Hungary (+ 5 further Hungarian addresses)
Type of method:
flask method
Key result
Water solubility:
> 500 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
10

Table 1: Water solubililty test

x (g) Test Item added to 5 mL water Observation x (g) Test Item added to 5 mL water Observation
1.00508 clear liquid phase 1.00061 clear liquid phase
2.01510 clear liquid phase 2.01157 clear liquid phase
3.02212 clear liquid phase 3.01322 clear liquid phase
4.02210 clear liquid phase 4.01714 clear liquid phase
5.02301 precipitation of test item 5.01723 precipitation of test item

The pH value of the clear liquid phase at the ca. 500 g/L (4.00001 g and 4.00006 g test item / 8 mL) concentration level was determined to be: 10.0. The expected volume of the solution of 9 mL was not observed. Due to volume contraction, the resulting volume of the solution was 8 mL.

Conclusions:
In conclusion, the water solubility of the test item was determined to be > 500 g/L (ca. 4 g / 8 mL) at room temperature based on the Preliminary Test (OECD 105).
Executive summary:

A study was conducted according to OECD TG 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 in order to determine the water solubility of the test item by using the shake flask method. During the water solubility test (Main Test / Shake-Flask method based on OECD 105) no saturated solution could be prepared. At the saturated concentration there was no liquid phase in the sample, therefore, the determination of the concentration was not feasible. Based on these observations the Preliminary Test with visual detection (OECD 105) was applied for the estimation of the water solubility. Based on the preliminary test, the water solubility of the test item was determined to be > 500 g/L (ca. 4 g / 8 mL) at room temperature.

Description of key information

The water solubility of the test item was determined to be > 500 g/L (ca. 4 g / 8 mL) at room temperature based on the Preliminary Test (OECD 105).

Key value for chemical safety assessment

Additional information

A study was conducted according to OECD TG 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 in order to determine the water solubility of the test item by using the shake flask method (reference 4.8-1). During the water solubility test (Main Test / Shake-Flask method based on OECD 105) no saturated solution could be prepared. At the saturated concentration there was no liquid phase in the sample, therefore, the determination of the concentration was not feasible. Based on these observations the Preliminary Test with visual detection (OECD 105) was applied for the estimation of the water solubility. Based on the preliminary test, the water solubility of the test item was determined to be > 500 g/L (ca. 4 g / 8 mL) at room temperature.