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EC number: 821-749-7 | CAS number: 154581-97-2
There was a statistically significant (p<0.01) difference between the inter-experimental SI. This is because a higher than average SI was determined in Test 4. There was also a steeper shape in the dose-response curve for the Test no. 4 data making it a p<0.01 for the quadratic component. Both significant differences were lost when data from Test 4 were excluded from the analysis. The results from Test 4 are considered be outliers.
Table 1. EC values derived:
Hexyl cinnamaldehyde is recommended as a positive control by the OECD guideline 406 for Skin Sensitisation. As such, the response of hexyl cinnamaldehyde in the Local Lymph Node Assay from five different experiments conducted in a single laboratory over a 10 month period was analysed. Hexylcinnamaldehyde in 0, 2.5, 5, 10, 25, 50% w/v in 4:1 acetone/olive oil was administered onto the dorsal ears of mice following a protocol equivalent to the OECD guideline 429 Skin Sensitisation: Local Lymph Node Assay adopted later. Hexyl cinnamaldehyde induced a positive response in all five tests (SI>3). The pooled stimulation indices were used to calculate the EC3 values using three different statistical approaches (Linear interpolation, Quadratic regression and Richard's model) which resulted in comparable EC3 values. Excluding the results of one of the tests which was considered to be an outlier, the EC3 range for hexylcinnamaldehyde was 6.6 -11.5% under the conditions of these experiments.
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