Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Principles of method if other than guideline:
The experiment was conducted following the procedures outlined into the "Handbook of Toxicology" by W.S. Spektor.
GLP compliance:
no
Remarks:
pre GLP
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Fluorescent Brightener 367
IUPAC Name:
Fluorescent Brightener 367

Test animals

Species:
rat
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 90 - 130 g

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
The product was administered as a 25 % suspension in 2 % mucilage of starch.
Doses:
15000 mg/kg bw
Details on study design:
After the application, the animals were kept under observation for another 7 days.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 15 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Clinical signs:
other: Animlas were normal.

Applicant's summary and conclusion

Conclusions:
LD50 (female) > 15000 mg/kg bw
Executive summary:

The experiment was conducted following the procedures outlined into the "Handbook of Toxicology" by W.S. Spektor. The product was administered as a 25 % suspension in 2 % mucilage of starch in female rats. The dose administrated was 15000 mg/kg bw. After the application, the animals were kept under observation for another 7 days. No animal died and animlas appeared normal.

Conclusion

LD50 (female) > 15000 mg/kg bw