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EC number: 614-626-2
CAS number: 685853-81-0
From extensive work on chromium III salts, there is no
evidence of acute toxicity. Some corrosive salts will cause harm at high
concentrations, but this is not considered to be a toxic effect.
Critic acid is not classified; although some reports on
anhydrous citric acid suggest Harmful (considered due to local
irritation / corrosion of the anhydrous acid)
view of the wealth of data on chromium salts and citric
acid, no further animal
testing is justified.
It is accepted that there is no dermal absorption of
metal salts such as chromium III from dermal contact.
The low oral toxicity also suggests low biological impact
from contact with chromium III. It is not considered to be justified to
perform further animal tests.
Skin penetration experiments on chromium chloride and
chromium sulfate (1.2% chromium labelled with 51Cr) with skin chambers
glued to the skin of normal volunteers. These chambers were removed at
6, 12, or 24 hours and analysis for radioactive chromium was performed
at the site of the chamber as well as in the underlying epidermis and
dermis. As no label was found in the lower levels of skin, it was
concluded that chromium(III) salts did not permeate through the intact
epidermis. Some blood samples and 24-h urine were also examined, and no
radioactive chromium was detected.[Mali JWH, Van Kooten WJ, Van Neer CJ
(1963) Some aspects of the behaviour of chromium compounds in the skin.
Journal of Investigative Dermatology, 41:111–122].
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