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CAS number: -
Table 1: Individual eye irritation scores
T=Test, C=Control; A=Redness; B=Chemosis; C=Discharge;
marked figures=used for calculation
In a primary eye irritation study according to OECD 405 0.1 g TDI-Urone
were applied unchanged into the conjunctival sac of 3 female New Zealand
White rabbits (Crl:KBL (NZW) BR). Eyes were not washed after treatment.
Animals were observed 72 h respectively and furthermore until the
disappearance of the symptoms. This was achieved at 48 h for animal No
375, at 96 h of animal No 358 and at 192 h for animal No 357. Irritation
was scored by the method of Draize.
The test item produced redness of the conjunctivae in all three animals
as well as opacity of the comea in one animal. Effects were fully
No comeal lesions were found upon fluorescein examination at the final
In this study TDI-Urone was found to be slightly irritating to the eyes
of rabbits but not relevant for classification.
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