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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007-03-28 to 2008-04-30
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
: Backweiging to determine concentration of the substance; pH was not determined;
Principles of method if other than guideline:
The saturated solution of the test substance in water was prepared at temperatures of 25, 40 and 60°C. The saturated solution was filtered and the flow through was dried in a vacuum oven. The test substance was weighed and the concentration was determined.
GLP compliance:
no
Type of method:
other: comparable to flask method
Key result
Water solubility:
ca. 23.2 g/L
Temp.:
25 °C
Remarks on result:
other: The pH value was not determined.
Water solubility:
ca. 25.5 g/L
Temp.:
40 °C
Remarks on result:
other: The pH value was not determined.
Water solubility:
ca. 34.1 g/L
Temp.:
60 °C
Remarks on result:
other: The pH value was not determined.
Conclusions:
The water solubility of TDI-Urone was determined. It is considered to be very soluble (> 10000 mg/L).
Executive summary:

The water solubility of TDI-Urone was determined with a method equivalent to the OECD guideline 105. The substance was stirred in water at temperatures of 25°C, 40°C and 65°C to to get a saturated solution. The supernatant was filtered and the eluat was dried at

45-55°C in a vacuum drying oven. The concentration of the substance was determined by reweighing.

The water solubility of TDI-Urone at 25°C was determined to be 2.32 g/100 g or 23.2 g/l water. Therefore, TDI-Urone is very soluble in water.

Description of key information

The water solubility of TDI-Urone was determined to be 23.2 g/l at 25°C.

Therefore, TDI-Urone is considered to be very soluble in water.

Key value for chemical safety assessment

Water solubility:
23.2 g/L
at the temperature of:
25 °C

Additional information

The water solubility of TDI-Urone was determined with a method equivalent to the OECD guideline 105. The substance was stirred in water at temperatures of 25°C, 40°C and 65°C to get a saturated solution. The supernatant was filtered and the eluat was dried at

45-55°C in a vacuum drying oven. The concentration of the substance was determined by reweighing.

The water solubility of TDI-Urone at 25°C was determined to be 2.32 g/100 g or 23.2 g/l water. Therefore, TDI-Urone is very soluble in water.