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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31. August to 17. December 1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Study was not conducted under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorododecane
EC Number:
203-981-5
EC Name:
1-chlorododecane
Cas Number:
112-52-7
Molecular formula:
C12H25Cl
IUPAC Name:
1-chlorododecane
Test material form:
liquid
Details on test material:
Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS:
- Strain: Rat / Wistar-Han
- Number and sex: 50 animals (25 males and 25 females)
- Body weigth: Males 161 - 202 g, Females 153 - 182 g
- Age: 6 - 8 weeks
- Acclimation period: 1 week

ENVIRONMENTAL CONDITIONS:
- Diet: pelleted standard Kliba 24/343/1
- Water: tab water ad libitum
- Housing in groups of 5 animals in MAKROLON cages (type III)
- Temperature: 22°C ± 2°C
- Rel. Humidity: 55% ± 10%
- Light/dark period: 12/12h

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Polyethyleneglycol 400
Doses:
500, 3000, 5000, 10000, 20000 mg/kg
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 20 000 mg/kg bw
Mortality:
No mortality ocurred.
Clinical signs:
other: Main symptoms: Dyspnoea, exophthalmus, curved body position from 500 mg/kg, sedation from 3000 mg/kg bw. Onset of symptoms 1 h after dosing, reversible within 5 to 7 days. No macroscopical organ changes were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the described test conditions, mortality did not occur up to the highest dose tested of 20000 mg/kg/bw. Thus, the LD50 is above 20000 mg/kg/bw, and according to Regulation (EC) 1272/2008 the data are conclusive but not sufficient for classification.