Registration Dossier
Registration Dossier
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EC number: 253-523-3 | CAS number: 37482-11-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
- Reference Type:
- publication
- Title:
- Skin Irritation: Reference Chemicals Data Bank
- Author:
- Bagley et al.
- Year:
- 1 996
- Bibliographic source:
- Toxicology in Vitro 10(1996) 1-6
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium 2-mercaptoethanolate
- EC Number:
- 253-523-3
- EC Name:
- Sodium 2-mercaptoethanolate
- Cas Number:
- 37482-11-4
- Molecular formula:
- C2H6OS.Na
- IUPAC Name:
- sodium 2-sulfanylethan-1-olate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test item (as cited by study report): 2-mercaptoethanol sodium
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 1.05 mL
- Concentration: 45.21% (aueous solution) - Duration of treatment / exposure:
- 3 min
- Observation period:
- 12 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: the flank
SCORING SYSTEM: Draize scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- <= 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 12 days
- Remarks on result:
- other: Crust formation no erythema scoring possible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Dryness of skin observed during the second and third day
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Dryness of the skin observed at day 7
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- One hour after removal of the patch after a 4 hour application to a single animal, signs of lesions through the whole depth of the skin were observed and the animal was sacrificed for humanitarian reasons. After a 3 minute exposure no ulceration or necrosis was seen.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
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