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EC number: 238-830-2 | CAS number: 14765-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The Freskomenthe, Acute Oral Toxicity In Rats test owned by RIFM dated on 1978 has determined a Freskomenthe LD50 (rat) = 2400mg/Kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Rats were dosed at 1.22, 1.95, 3.12, 5 g/Kg
- GLP compliance:
- no
- Remarks:
- Test performed prior to the GLP guideline
- Test type:
- fixed dose procedure
- Limit test:
- no
- Specific details on test material used for the study:
- Sample marking: 77-182, Freskomenthe
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1.22 mg/kg
1.95 mg/kg
3.12 mg/kg
5.00 mg/kg - No. of animals per sex per dose:
- 10 males per group (per dose)
- Control animals:
- no
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 1 900 - ca. 3 000
- Remarks on result:
- other: 95% confidence limits
- Mortality:
- 1220 mg/kg - 0/10 animals died.
195 mg/kg - 4/10 animals died.
3120 mg/kg - 8/10 animals died.
5000 mg/kg - 10/10 animals died. - Clinical signs:
- other: All doses: lethargy, ataxia, coma, ptosis, piloerection, diarrhea (see details in "Any other information on results" field below)
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- In conclusion the LD50 has been detrmined to be LD50(rat)= 2400 mg/kg bw (1900-3000 mg/kg bw).
Freskomenthe meets the criteria to be classified Category 5 according to the GHS classification. - Executive summary:
LD50 has been detrmined to be LD50(rat)= 2400 mg/kg bw (1900-3000 mg/kg bw).
Freskomenthe meets the criteria to be classified Category 5 according to the GHS classification.
Reference
Dose: 1.22 g/kg; clinical signs:
Clinical signs observed included lethargy, ataxia, coma, ptosis, chromorhinorrhea, piloerection, diarrhea and chromodacryorrhea. Necropsy revealed 9/10 animals were normal; red exudate in the nose/mouth in 1/10 animals.
Dose: 3.12 g/kg clinical signs; lethal
8/10 deaths; Deaths occurred on days 1 and 2. Clinical signs observed included coma, prostration, ataxia, chromorhinorrhea, chromodacryorrhea, lethargy, diarrhea and emaciation. Necropsy revealed 2/10 animals were normal; red exudate in the nose/mouth in 8/10 animals; brown anogenital exudate in 3/10 animals; red areas in the intestines in 8/10 animals; yellow areas in the intestines in 8/10 animals; gelatinous intestines in 3/10 animals; bloated intestines in 5/10 animals; yellow fluid in the intestines in 3/10 animals; red areas in the stomach in 5/10 animals; mottled liver in 8/10 animals; dark areas in the lungs in 8/10 animals; mottled kidney in 7/10 animals; white nodule on the outer surface of the kidney in 1/10 animals; dark spleen in 3/10 animals; mottled spleen in 5/10 animals; creamy yellow fluid in stomach in 2/10 animals.
Dose: 1.95 g/kg clinical signs; lethal
4/10 deaths; Deaths occurred on days 2 and 12. Clinical signs observed included coma, prostration, ataxia, chromorhinorrhea, diarrhea, chromodacryorrhea, ptosis and emaciation. Necropsy revealed 3/10 animals were normal; 1/10 animals cannibalized; red exudate in the nose/mouth in 3/10 animals; yellow exudate in the nose/mouth in 2/10 animals; brown anogenital exudate in 3/10 animals; red areas in the intestines in 3/10 animals; yellow areas in the intestines in 3/10 animals; gelatinous intestines in 3/10 animals; orange fluid in the stomach in 2/10 animals; yellow fluid in the stomach in 1/10 animals; mottled liver in 3/10 animals; dark lungs in 3/10 animals; dark kidney in 4/10 animals; mottled kidney in 1/10 animals; mottled spleen in 3/10 animals; bladder-blood contained in urine in 1/10 animals.
Dose: 5 g/kg clinical signs; lethal
10/10 deaths. Deaths occurred on days 1 and 2. Clinical signs observed included coma, ataxia, lethargy, ptosis and chromorhinorrhea. Necropsy revealed red exudate in the nose/mouth in 2/10 animals; brown anogenital exudate in 1/10 animals; red areas in the intestines in 5/10 animals; yellow areas in the intestines in 10/10 animals; bloated intestines in 7/10 animals; red areas in the stomach in 9/10 animals; stomach, area approximately 10% bubbled out and thin in 4/10 animals; dark liver in 1/10 animals; mottled liver in 8/10 animals; dark liver in 3/10 animals; dark areas in the lungs in 7/10 animals; mottled kidney in 5/10 animals; pale kidney in 2/10 animals; mottled spleen in 5/10 animals; creamy yellow fluid in the stomach in 7/10 animals.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 400 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
LD50 has been detrmined to be LD50(rat)= 2400 mg/kg bw (1900-3000 mg/kg bw).
Freskomenthe meets the criteria to be classified Category 5 according to the GHS classification.
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