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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 23-31, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Name (as stated in the report): Freskomenthe
Batch: VE00419857
Purity: 99.0%
Expiration date: September 14, 2018
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.2
Temp.:
35 °C
pH:
7
Details on results:
Details results are given in Appendix 1 and illustrated by the graph in the Appendix 2 of the attached report.
Conclusions:
In the conditions of the test, the chromatograms of Freskomenthe show one peak at an average retention time of 5.067 minutes, corresponding to a partition coefficient (log value) of 3.2.

Therefore:

Partition coefficient n-octanol/water of Freskomenthe:

log Pow = 3.2
Executive summary:

The Partition Coefficient n-octanol/water of Freskomenthe was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 

The result is:

Partition coefficient n-octanol/water of Freskomenthe:     

 

log Pow= 3.2

Description of key information

The Partition Coefficient n-octanol/water of Freskomenthe was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 

The result is:

Partition coefficient n-octanol/water of Freskomenthe:     

 

log Pow= 3.2

Key value for chemical safety assessment

Log Kow (Log Pow):
3.2
at the temperature of:
35 °C

Additional information