Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-600-9 | CAS number: 13863-31-5
The effects of the test article on the integrity and performance of male and female reproductive systems, including gonadal function, estrous cycle, mating behaviour, conception, gestation, parturition, lactation, weaning and growth and development of the spring were assessed testing rats, according to the EPA OPPTS 870.3800 (Reproduction and Fertility Effects) guideline.
Animals were exposed to the test articloe daily, via oral gavage at the dose levels of 0, 100, 300 and 1000 mg/kg bw, at a constant volume of 10 ml/kg. The duration of the whole study was approx. 9 months.
Based on the results, the No Observed Adverse Effect Level (NOAEL) for parental toxicity was 300 mg/kg day and for parental reproductive performance, the NOAEL was l000 mg/kg day. For offspring growth and development, the NOAEL was also 1000 mg/kg day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again