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EC number: 237-600-9 | CAS number: 13863-31-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- other: five days.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system (only 5 consecutive days).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
- Principles of method if other than guideline:
- The effect of the 5 -days repeated skin administration to five rats was evaluated. 20 mg were given to each animal.
- GLP compliance:
- no
- Remarks:
- Pre GLP.
Test material
- Reference substance name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- EC Number:
- 237-600-9
- EC Name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- Cas Number:
- 13863-31-5
- Molecular formula:
- C38H40N12Na2O8S2
- IUPAC Name:
- disodium 2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[(2-hydroxyethyl)(methyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: gum arabic
- Details on exposure:
- TEST SITE
- Area of exposure: back.
TEST MATERIAL
- Amount applied: 0.4 ml
- Concentration: 5 %
- Constant volume or concentration used: yes. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 days.
- Frequency of treatment:
- Daily.
Doses / concentrations
- Dose / conc.:
- 20 mg/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
20 mg/animal
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Results of examinations
- Details on results:
- After 8 days no abnormalities detected.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 other: mg/animal
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: no effects up to the highest dose
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- After 8 days no abnormalities detected in animals exposed to 20 mg of the test substance.
- Executive summary:
Method
The effect of the 5 -days repeated skin administration to five rats was evaluated. 20 mg were given to each animal.
Result
After 8 days no abnormalities detected.
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