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EC number: 237-600-9 | CAS number: 13863-31-5
The radioactive material present in the faeces of the rats treated with the test substance was not extractable with methanol
Excretion of radioactivity by rats after oral dose
The behaviour of three water-soluble fluorescent whitening agents (FWAs - including the test item) was studied in rats using 14C-labelled compounds. The fate of 14C-labeled test substance was followed in the rat. The animals dosed with 5.97 ± 0.33 mg/kg (actual dose) and faeces, urine and expired CO2 were monitored. After 96 hours animals were killed and tissues analyzed.
Following oral doses of 5 mg/kg to rats rapid and complete excretion of radioactive material was observed with an excretion half life ranging from 7-13 hours. Faeces were practically the only route of excretion indicating, in combination with the short half life times, that no significant amounts of whitener were absorbed from the digestive tract. No radioactive residues were found in blood, liver, kidney, brain, muscle, or fat 96 hours after dosing (limit of quantitative determination 0.005-0.01 ppm FWA equivalents).
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