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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05-31 to 2017-08-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
11.1 µg/L
Temp.:
20 °C
pH:
6.25 - 6.5

RESULTS AND DISCUSSION

The matrix blank sample did not show any interferences.

The temperature of the water bath remained constant at 20.0 ± 0.1°C throughout the experiment. Under the instrumental conditions presented, the measured reagent water solubility of 1,12-dodecanediol bismethacrylate was <11.1 µg a.i./L. The response was consistent for samples collected at both flow rates (1.0 mL/minute and 0.5 mL/minute). The overall mean measure water solubility at 20°C was <11.1 µg a.i./L (N = 10). The pH was measured for an aqueous sample collected at 0.5 mL/min. The measured pH of reagent water and an aqueous sample was 6.25 and 6.50, respectively.

Table 3 Definitive Water Solubility of 1,12-Dodecanediol Bismethacrylate (CAS# 72829-09-5) at 20ºC

 

 

Sample ID

(524C-142)

Measured

Flow

Rate

(mL/min)

Concentration of 1,12-Dodecanediol Bismethacrylate

% Difference1

Measured Concentration

(µg/L)3

Mean Measured ± SD

(mg/mL)1,2

 

11

12

13

14

15

 

16

17

18

19

20

 

1.0

1.0

1.0

1.0

1.0

 

0.5

0.5

0.5

0.5

0.5

 

<11.1

<11.1

<11.1

<11.1

<11.1

 

<11.1

<11.1

<11.1

<11.1

<11.1

 

N/A

 

 

 

 

 

N/A

N/A

Overall Mean1,2=

SD1,2=

CV1,2=

N2=

<11.1

N/A

N/A

10

 

1   Results were generated using Microsoft®Excel 2010 in full precision mode. Manual calculations may differ slightly.

2   SD = Standard Deviation

    CV = Coefficient of Variation.

    N = Number of Measurements

    % Difference = Percent difference of mean measured concentrations from the two flow rate settings:

                = (absolute value of the difference of means¸average of means) x 100.

3  Results were generated in Analyst 1.4.1.


Conclusions:
CONCLUSIONS
The water solubility of 1,12-dodecanediol bismethacrylate in reagent water at 20ºC was <11.1 µg a.i./L.
Executive summary:

The water solubility of the test substance in reagent water at 20ºC was determined using the column elution method. The overall mean water solubility for 1,12-Dodecanediol Bismethacrylate (CAS# 72829-09-5) at 20.0 ± 0.1°C was determined to be <11.1 µg a.i./L (N = 10).

Description of key information

The water solubility of the test item at 20°C was determined in an experimental study performed in accordance with the following test guidelines: OECD 105, OPPTS 830.7840, and GLP requirements.

The overall mean water solubility for 1,12-Dodecanediol Bismethacrylate (CAS# 72829-09-5) at 20.0 ± 0.1°C was determined to be <11.1 µg/L.

Key value for chemical safety assessment

Water solubility:
11.1 µg/L
at the temperature of:
20 °C

Additional information