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Short-term toxicity to aquatic invertebrates

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Description of key information

EC50 (48 h) > 100 mg/L (nominal) for Daphnia magna (OECD 202)

Key value for chemical safety assessment

Additional information

One key study is available for 2-{2-chloro-4-mesyl-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione, in which the short term toxicity to invertebrates was investigated. The study (M-212589-01-1; 2003) was conducted according to GLP and OECD guideline 202. In a static test system in freshwater, the test organism Daphnia magna was exposed to five nominal concentration of 10, 18, 32, 56, and 100 mg/L. Analyses of freshly prepared water for the test item resulted in test item concentrations ranging from 78.5% to 98.3% of nominal values. Analyses of aged water (48 h) at experimental termination resulted in test item concentrations ranging from 71.3% to 95.6% of nominal values. The mean measured values over the time of exposure ranged from 74.9% to 97.0%. Recovery percentages below 80% were found at the nominal treatment level of 10 mg/L only. Since this treatment level is below the range of biological endpoints, all effect concentrations were based on nominal initial test concentrations. One individual was immobilised at 56 mg/L. The concentration estimated to immobilise 50% of the test animals (EC50) after 48 hours is >100 mg/L.