Registration Dossier
Registration Dossier
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EC number: 695-022-6 | CAS number: 473278-76-1
Endpoint summary
Administrative data
Description of key information
Screening test on ready biodegradability
In a biodegradation screening study according to OECD 301 F the substance was found to be not readily biodegradable under the test conditions.
Aerobic Biodegradation in soil (Japan MAFF Test Guideline, 12-Nousan-No. 8147 Part 2-5-2):
DT50 soil: 12.3 – 18.3 days at 25 °C, M-398551-01-1
temperature corrected values DT50 soil: 40.9 – 60.9 days at 12 °C, M-398551-01-1
Aerobic Biodegradation in soil (OECD 307; EPQ OPPTS 4100; Draft SANCO 11802/20;Japan MAFF Test Guideline, 12-Nousan-No. 8147 Part 2-5-2):
DT50 soil: 2.7 - 14.7 days at 20.3 °C, M-443672-01-1
temperature corrected values DT50 soil: 5.9 – 32.1 days at 12 °C, M-443672-01-1
Anaerobic Biodegradation in soil (OECD 307; EPQ OPPTS 4200;Japan MAFF Test Guideline, Annex No.: 2-5-3):
DT50 soil: > 1000 days at 20 °C, M-482008-01-1
Additional information
Screening test on ready biodegradability
One GLP guideline study is available, which assessed the "Ready Biodegradability" of the test substance according to OECD guideline 301 F using activated sludge. The non-adapted activated sludge was inoculated with a nominal concentration of 100 mg/L test substance, equivalent to 1.698 mg O2/mg ThOD, during 28 d under aerobic conditions in the dark.
The toxicity control showed no toxic effects on bacteria at the tested concentration. Results showed 4% degradation after 7 and 14 d, 6% after 21 d and 4% after 28 d. Therefore, the test substance is considered to be not readily biodegradable.
Aerobic biodegradation in soil
The substance was degraded in soil under aerobic conditions in the dark in the laboratory (M-398551-01-1; M-443672-01-1). Its calculated half-lives ranged between 2.7 and 18.3 days under the chosen test conditions, which correspond to temperature corrected DT50 values of 5.9 – 60.9 at 12°C (average environmental temperature in Europe). Formation of carbon dioxide was observed and ranged from 11.5 to 63.2%AR during the aerobic incubation phase (DAT-120).
Two major degradation products were detected: benzoic acid and benzyl alcohol. Benzoic acid formation ranged from 4.4 to 7.3% of AR. The formation of benzyl alcohol equaled a maximum of 61.0% of AR. The formation of additional volatile metabolites was negligible. Formation of non-extractable residues ranged from 28.9 to >34% AR at the end of the aerobic incubation phase.
The results indicate that the substance is not expected to have a potential for accumulation in the terrestrial environment.
Anaerobic biodegradation in soil
The substance was not significantly degraded in soil under anaerobic conditions in the dark in the laboratory (M-482008-01-1). The calculated half-lives under anaerobic conditions were > 1000 days.
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