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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From May 07th to July 28th, 2018
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
according to guideline
OECD Guideline 105 (Water Solubility)
Version / remarks:
adopted July 27 1995
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
8.84 g/L
Conc. based on:
test mat.
Incubation duration:
24 - 72 h
20 °C
ca. 8.3
Details on results:
The repeatability of the determination was < 15 % and thus within the range required by the guidelines.

Results of the determination of water solubility of test item

Sampling time  Measured concentration of test item, g/l Measured pH
Test vessels Mean
after 24 hours 9.47 9.32 8.2
9.09 8.2
9.38 8.2
after 48 hours 7.12 8.08 8.4
8.62 8.4
8.50 8.4
after 72 hours 9.58 9.12 8.4
8.22 8.4
9.56 8.4
Mean with confidence interval (95 %) - 8.84 ± 1.65 -
RSD % - 8 -
8.84 g/l at 20 °C and pH ca 8.3
Executive summary:

The water solubility of the test item was determined by flask method, according to the OECD guideline 105.

A preliminary assay was carried out as a range finding test and the solubility of the test item was higher than 10 mg/l; therefore, the flask method was used for the main test.

About 2 g test item was weighed into stoppered Erlenmeyer flasks (nine parallels); after the addition of 50 ml ultrapure water, the flasks were agitated at 30 °C.

After one day, three of the vessels were removed and re-equilibrated at 20 °C for 24 hours. The content of the vessel was then centrifuged at 20 °C and the concentration in the clear aqueous phase was determined by a validated HPLC-UV/Vis validated method.

The other flasks were treated similarly after initial equilibration at 30 °C for two and three days, respectively. The samples were diluted before the analysis (two parallel dilutions). The pH of each sample was recorded.

The water solubility of test item was determined to be 8.84 ± 1.65 g/l (95 % confidence interval) at 20 ± 0.5 °C and pH ca 8.3. The repeatability of the determination was < 15 % and thus within the range required by the guidelines.


8.84 g/l at 20 °C and pH ca 8.3

Description of key information

8.84 g/l at 20 °C and pH ca 8.3

Key value for chemical safety assessment

Water solubility:
8.84 g/L
at the temperature of:
20 °C

Additional information

OECD 105 - flask method