Registration Dossier
Registration Dossier
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EC number: 640-509-0 | CAS number: 26621-44-3
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- 5-nitro-1H-pyrazole
- EC Number:
- 640-509-0
- Cas Number:
- 26621-44-3
- Molecular formula:
- C3H3N3O2
- IUPAC Name:
- 5-nitro-1H-pyrazole
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- ca. 5.86 g/L
- Conc. based on:
- not specified
- Loading of aqueous phase:
- 0.4 g/L
- Incubation duration:
- ca. 24 h
- Temp.:
- 20 °C
- pH:
- ca. 5.8
Any other information on results incl. tables
1) The result of the preliminary test has proved that the water solubility is 1 g/L～10 g/L; the test method can then be designed as following: about 1.5 g of the sample should be taken and 100 mL of water be used.
2) The concentrations of the standard solutions are 0.02 g/50 mL, so the centrifuged solutions should be diluted as following: Pipette 2.00 mL of the centrifuged solution into a 25 mL volumetric flask, then dilute to mark with methanol and mix well: n = 12.5.
3) Determination results
The relative difference of the concentrations measured in the three flasks respectively:
A-B, 1.3 %; A-C, -2.8 %; B-C, -4.1 %
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the sample is 5.86 g/L (20°C, pH = 5.8).
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