Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Results and discussion

Water solubility
Key result
Water solubility:
ca. 5.86 g/L
Conc. based on:
not specified
Loading of aqueous phase:
0.4 g/L
Incubation duration:
ca. 24 h
Temp.:
20 °C
pH:
ca. 5.8

Any other information on results incl. tables

1) The result of the preliminary test has proved that the water solubility is 1 g/L~10 g/L; the test method can then be designed as following: about 1.5 g of the sample should be taken and 100 mL of water be used.

2) The concentrations of the standard solutions are 0.02 g/50 mL, so the centrifuged solutions should be diluted as following: Pipette 2.00 mL of the centrifuged solution into a 25 mL volumetric flask, then dilute to mark with methanol and mix well: n = 12.5.

3) Determination results

The relative difference of the concentrations measured in the three flasks respectively:

A-B, 1.3 %; A-C, -2.8 %; B-C, -4.1 %

Applicant's summary and conclusion

Conclusions:
The water solubility of the sample is 5.86 g/L (20°C, pH = 5.8).