Registration Dossier
Registration Dossier
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EC number: 916-331-7 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The BCF growth and lipid corrected is 309 based on OECD TG 305 and Gobas and Lee, 2019.
Key value for chemical safety assessment
- BCF (aquatic species):
- 305 L/kg ww
Additional information
The bioconcentration of radiolabelled Cyclabute in rainbow trout (Oncorhynchus mykiss) was determined in a GLP-compliant OECD guideline 305 study.
Method: In this flow-through test, groups of fish were exposed for a 60 day uptake phase to nominal test concentrations of 0, 3.6 and 36 µg/L of the test substance followed by a 60 day depuration phase. The average fish length and weight at the start were 6.8 cm and 2.91 grams.
Results: The average concentrations during the test were 3 and 29 ug/l. At the end of the uptake and depuration phase the average weight is 8.5 gram (4.7-16) and 35 gram (24.8-48.2 gram), respectively.
BCFss: The uptake phase was 60-days but steady state was not fully achieved. The depuration phase was also 60-days. BCFss values for the 3 µg/L and 29 ug/l test concentration for the whole fish tissue were 215 and 201, respectively.
The kinetic BCF-K values are k1, 7.8 and 7.2; k2, 0.028 and 0.027 and kg 0.02143 and 0.02142 for the high and low concentration respectively. The kinetic BCF calculated is corrected for growth dilution according to Gobas and Lee as follows: k1/k2g*(1-kg/k2) and result for the whole fish 279 and 267 for the low and high concentration, respectively. These values need to be adjusted to 5% lipid content. The lowest lipid content is the solvent control and is 4.6%, at the end of the uptake phase. The final BCFkinetic lipid and growth corrected for the 3 and 29 ug/l result in 309 and 296 l/kg (minor differences occur due to rounding off values).
Final BCF-K lipid and growth corrected for 3 ug/l is 309 l/kg being the higher value.
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