Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 605-146-4 | CAS number: 158451-78-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non-GLP
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- May 12, 1981
- Qualifier:
- according to guideline
- Guideline:
- other: Off. J. Europ. Commun. L 257, 83/467/EEC
- Version / remarks:
- September 16, 1983
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,6-Hexanediamine, N1,N1,N6,N6-tetramethyl-, propoxylated (>1 < 4,5 mol PO)
- EC Number:
- 605-146-4
- Cas Number:
- 158451-78-6
- Molecular formula:
- C16H38N2O2
- IUPAC Name:
- 1,6-Hexanediamine, N1,N1,N6,N6-tetramethyl-, propoxylated (>1 < 4,5 mol PO)
Constituent 1
- Specific details on test material used for the study:
- - SIS No.: 20755
- RIS No.: 51Z9900452000
- Delivery: shortly before treatment
- Aggregate state at 20 °C: liquid
- Colour: yellowish
- Active substance content: 20%
- Stability in solvent: stable in aqua dest., preferred
- Storage: room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: approximately 10 weeks
- Weight at study initiation: mean male: 199 g; mean female: 156 g [1st experiment, low dose]; mean male: 225 g; mean female: 163 g [2nd experiment, high dose]
- Fasting period before study: 15 hours before dosing
- Housing: Groups of 2 animals in Makrolon cages Type 3 with standard woftwood bedding, ARWI-center, Essen, Germany
- Diet: Pelleted Altromin Maintenance Diet 1314 (Fa. Altromin GmbH, Germany); ad libitum
- Water: Community tap water from Düsseldorf; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-25
- Humidity (%): 45-71
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Aqua dest.
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 200 and 2000 mg/kg body weight
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality/toxicity symptoms were checked at frequent intervals during test day one and twice daily during days 2-14 (working days). The animals were weighed on the day before the application, on the day of application, on day 2, 7 and 14 after application
- Necropsy of survivors performed: yes, macroscopic examination of all external orifices and the organs in thoracic and visceral cavity. - Statistics:
- Not applicable.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- other: Some animals (males and females) showed after the application reduced activity, piloerection and difficulty of breathing (dyspnoea). Three hours later there were no symptoms observed.
- Gross pathology:
- - males, dose 200 mg/kg: no macroscopic findings were considered to be treatment related. One male had no feces in the rectum and the rectum was slight dilated.
- females, dose 200 mg/kg: no macroscopic findings were considered to be treatment related.
- males, dose 2000 mg/kg: no macroscopic findings were considered to be treatment related.
- females, dose 2000 mg/kg: no macroscopic findings were considered to be treatment related. Two females showed hydrometra.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
