Registration Dossier
Registration Dossier
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EC number: 605-146-4 | CAS number: 158451-78-6
Endpoint summary
Administrative data
Description of key information
The test substance was not acute toxic in an OECD 401 guideline study up to a dose of 2000 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute toxicity study, performed according to OECD guideline 401, a limit test was performed on 2 male and 2 female Wistar rats that were exposed to 2000 and 200 mg/kg bw test substance, which was administered orally (gavage). Some animals showed some clinical signs right after administration of the test substance (decreased activity, piloerection and shallow breathing), but these symptoms had dissapeared after 3 hours. During the study period of 14 days, no mortality was observed and the animals gained weight. At necropsy, no macroscopic findings were considered to be treatment related. The LD50 was determined to be >2000 mg/kg body weight.
No acute toxicity testing via inhalation or the dermal route were performed, as the substance is corrosive to the skin.
Justification for classification or non-classification
Based on the available information classification for acute toxicity is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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