Registration Dossier
Registration Dossier
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EC number: 204-077-3 | CAS number: 115-27-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically undertaken and reported study but not to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- EC Number:
- 204-077-3
- EC Name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- Cas Number:
- 115-27-5
- Molecular formula:
- C9H2Cl6O3
- IUPAC Name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- Details on test material:
- - Name of test material (as cited in study report): Chlorendic anhydride- Analytical purity: 98.81%- Lot/batch No.: 3-12-206
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Source: Sweetwater Farms, Hillsboro, Ohio- Age at study initiation: - Weight at study initiation: 2049 to 2523 g- Housing: hanging wire-mesh cages.- Diet: Purina Rabbit Chow, ad libitum - Water: ad libitum- Acclimation period:ENVIRONMENTAL CONDITIONS- Temperature (°C): - Humidity (%): - Air changes (per hr): - Photoperiod (hrs dark / hrs light):IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye served as a control for each rabbit.
- Amount / concentration applied:
- TEST MATERIAL- Amount(s) applied (volume or weight with unit): 100 mg- Concentration (if solution):VEHICLE- Amount(s) applied (volume or weight with unit):- Concentration (if solution):- Lot/batch no. (if required): - Purity:
- Duration of treatment / exposure:
- 14 days following instillation.
- Observation period (in vivo):
- 14 days following instillation.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing (if done): None- Time after start of exposure:SCORING SYSTEM: J.H. Draize scale for scoring ocular lesions.TOOL USED TO ASSESS SCORE: Fluorescein and UV lamp.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 14 days
- Score:
- 16.4
- Max. score:
- 17.3
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: not specified
- Conclusions:
- Based upon the data, the test material would be considered a primary eye irritant.
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