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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-06-23 to 2003-06-27
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study was performed as pretest for a OECD 305 bioconcentration study. The pre test was performed according to GLP and the methods applied are fully compliant with OECD TG 203.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
Solubilizer used to achieve exposure
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4,5-trifluoro-4'-[(1s,4r)-4-propylcyclohexyl]-1,1'-biphenyl
EC Number:
603-547-9
Cas Number:
132123-39-8
Molecular formula:
C21H23F3
IUPAC Name:
3,4,5-trifluoro-4'-[(1s,4r)-4-propylcyclohexyl]-1,1'-biphenyl
Specific details on test material used for the study:
Puritiy: 99.78 % (GC)

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
yes
Details on test solutions:
HCO-40: 10 g/L
Test Material: 13, 20, 32, 50, 79 mg/L

Test organisms

Test organisms (species):
Oryzias latipes
Details on test organisms:
Species: Oryzias latipes
Charge: 0304081
Weight: 0.2 g
Length: 2.8 (2.5 - 3.0) cm

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h

Test conditions

Hardness:
According to guideline
Test temperature:
25 °C
pH:
According to guideline
Dissolved oxygen:
According to guideline
Salinity:
According to guideline
Nominal and measured concentrations:
Test Material: 13, 20, 32, 50, 79 mg/L nominal stabilised with solubiliser 10 g HCO-40 / L

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
37 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: solubiliser was used to achieve max exposure

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The LC50 (96 h) of the test material with solubilizer was at 37 mg/L clearly exceeding the water solubility of the pure test substance.
Executive summary:

The informtion for this endpoint study record was obtained from an experimental study. The OECD GLP criteria were met and the methods applied are fully compliant with OECD TG 203. The LC50 (96 h) of the test material with solubilizer was at 37 mg/L clearly exceeding the water solubility of the pure test substance.