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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of CAS no 3520-42-1 in mouse
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of C.I. Acid Red 52 (3520-42-1) in mice
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt
EC Number:
222-529-8
EC Name:
Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt
Cas Number:
3520-42-1
Molecular formula:
C27H30N2O7S2.Na
IUPAC Name:
sodium 4-[3,6-bis(diethylamino)-2,7-dimethylxanthenium-9-yl]benzene-1,3-disulfonate; 2-(3-diethylamino-6-diethylazaniumylidene-xanthen-9-yl)-5-sulfo-benzenesulfonate
Details on test material:
- Name of test material:C.I. Acid Red 52
- Molecular formula :C27H30N2O7S2.Na
- Molecular weight :580.6551 g/mole
- Smiles notation: CCN(CC)c1ccc2c(c1)[o+]c3cc(ccc3c2c4ccc(cc4S(=O)(=O)[O-])S(=O)(=O)[O-])N(CC)CC.[Na+]
-InChl:1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
- Substance type:Organic
Specific details on test material used for the study:
- Name of test material:C.I. Acid Red 52
- Molecular formula :C27H30N2O7S2.Na
- Molecular weight :580.6551 g/mole
- Smiles notation: CCN(CC)c1ccc2c(c1)[o+]c3cc(ccc3c2c4ccc(cc4S(=O)(=O)[O-])S(=O)(=O)[O-])N(CC)CC.[Na+]
-InChl:1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
- Substance type:Organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
10300 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality was observed in treated mice at dose 10300 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
the LD50 value was considered to be 10300 mg/kg bw when mice was treated with C.I. Acid Red 52 orally.
Executive summary:

In a acute oral toxicity study,mice were treated with C.I. Acid Red 52 in the concentration of 10300 mg/kg bw orally. No mortality was observed in treated mice. Therefore,LD50 was considered to be10300 mg/kg bw when mice were treated with C.I. Acid Red 52 orally.