Registration Dossier
Registration Dossier
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EC number: 201-849-1 | CAS number: 88-66-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2-(dichloromethyl)benzene
- EC Number:
- 201-849-1
- EC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Cas Number:
- 88-66-4
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Details on test material:
- Purity 99.8 %
AZ 04803 of September 5th, 1990, Analytisches Laboratorium Hoechst AG
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Strain: Hoe: WISKf (SPF71)
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: males: 186 g - 206 g (average 198 g); females: 183 g - 202 g (average 193 g)
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 50 +/- 20%
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas chromatography with external standard
- Duration of exposure:
- 4 h
- Concentrations:
- 1.74, 3.0, 7.3 mg/L
- No. of animals per sex per dose:
- 5 animals per sex per dose in the treatment groups
- Details on study design:
- - Duration of observation period following administration: all animals 14 days and group with highest exposure 21 days
- Frequency of observations: exact observation during inhalation period
- Frequency of weighing: before exposure, day 7, 14 and 21 post exposure
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.3 mg/L air (analytical)
- Exp. duration:
- 4 h
- Mortality:
- no animals died during exposure or post exposure period
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study the 4h LC50 of 2-chlorobenzal chloride is greater than 7.3 mg/L.
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