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EC number: 907-728-6 | CAS number: -
- At topical application of 60% no edema was observed at any time point and in three animals a very slight erythema (grade 1) was observed immediately after patch removal and in all four exposed animals after 24 and 48 hours, of which in one animal a well-defined erythema (grade 2) was observed after 24 and 48 hours, and in one animal a necrotic patch was observed. Therefore, this concentration was used for the topical induction concentration. As at 50% no erythema was observed at any time of observation, this concentration was used for the highest challenge exposure.
- The body weight gain of the animals was normal, no signs of ill health, no systemic toxicity and no mortality was seen.
- The ten animals exposed to negative control did not show any signs of irritation.
- Intradermal injections: Application area around the injection sites (at 7.5%) was found to show a slight irritation.
The skin sensitisation potential of Prismantol was tested in a guinea pig maximisation test performed similar to OECD 406 (1981) and according to GLP principles. A concentration of 7.5% was used for the intradermal induction, 60% for the epidermal induction and 25 and 50% for the topical challenge. The substance produced evidence of skin sensitization in all tested twenty animals and therefore was considered a skin sensitiser. Because ≥ 30% (100%) of animals responded at a dose of > 1% (7.5%), Prismantol is 1B sensitizer.
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